Research papers
A. Iakovliev, S. McGurnaghan, C. Hayward, M. Colombo, D. Lipschutz, A. Spiliopoulou, H.M. Colhoun, P.M. McKeigue
Genome-wide aggregated trans- effects on risk of type 1 diabetes: a test of the 'omnigenic' sparse effector hypothesis of complex trait genetics
To appear in The American Journal of Human Genetics
R. Stein, F. Koutny, J. Riedel, N. Dörr, K. Meyer, M. Colombo, M. Vogel, C.H. Anderwald, M. Blüher, W. Kiess, A. Körner, D. Weghuber
Single Point Insulin Sensitivity Estimator (SPISE) as a prognostic marker for emerging dysglycemia in children with overweight/obesity
Metabolites, 13 (1), 100, 2023
L.K. Küpers, S. Fernández-Barrés, G. Mancano, L. Johnson, R. Ott, J. Vioque, M. Colombo, K. Landgraf, E.W. Tobi, A. Körner, R. Gaillard, J.H.M. de Vries, V.W.V. Jaddoe, M. Vrijheid, G.C. Sharp and J.F. Felix
Maternal dietary glycemic index and glycemic load in pregnancy and offspring cord blood DNA methylation
Diabetes Care, 45 (8), 1822-1832, 2022
E. Valo°, M. Colombo°, N. Sandholm, S.J. McGurnaghan, L.A.K. Blackbourn, D. Dunger, P.M. McKeigue, C. Forsblom P-H. Groop, H.M. Colhoun, C. Turner and R.N. Dalton on behalf of the SDRNT1BIO Investigators and FinnDiane Study Group
Effect of serum sample storage temperature on metabolomic and proteomic biomarkers
Scientific Reports, 12, 4571, 2022
S.J. McGurnaghan, P.M. McKeigue, S.H. Read, S. Franzen, A-M. Svensson, M. Colombo, S. Livingstone, B. Farran, T.M. Caparrotta, L.A.K. Blackbourn, J. Mellor, I. Thoma, N. Sattar, S.H. Wild, S. Gudbjornsdottir and H.M. Colhoun, on behalf of the Swedish National Diabetes Register and the Scottish Diabetes Research Network Epidemiology Group
Development and validation of a cardiovascular risk prediction model in type 1 diabetes
Diabetologia, 64 (9), 2001-2011, 2021
S.J. McGurnaghan, A. Weir, J. Bishop, S. Kennedy, L.A.K. Blackbourn, D. McAllister, S. Hutchinson, T.M. Caparotta, J. Mellor, A. Jeyam, J.E. O'Reilly, S. Wild, S. Hatam, A. Höhn, M. Colombo, C. Robertson, N. Lone, J. Murray, E. Butterly, J. Petrie, B. Kennon, R. McCrimmon, R. Lindsay, E. Pearson, N. Sattar, J. McKnight, S. Philip, A. Collier, J. McMenamin, A. Smith-Palmer, D. Goldberg, P.M. McKeigue, H.M. Colhoun, Public Health Scotland COVID-19 Health Protection Study Group, Scottish Diabetes Research Network Epidemiology Group
Risks of and risk factors for COVID-19 disease and development of a risk prediction model in people with diabetes in Scotland: A cohort study
Lancet Diabetes & Endocrinology, 9 (2), 82-93, 2021
M. Colombo°, A. Asadi Shehni°, I. Thoma, S.J. McGurnaghan, L.A.K. Blackbourn, H. Wilkinson, A. Collier, A.W. Patrick, J.R. Petrie, P.M. McKeigue, R. Saldova and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators
Quantitative levels of serum N-glycan in type 1 diabetes and their association with kidney disease
Glycobiology, 31 (5), 613-623, 2021
M.L. Marcovecchio, M. Colombo, R.N. Dalton, P.M. McKeigue, P. Benitez-Aguirre, F. Cameron, S.T. Chiesa, J. Couper, M. Craig, D. Daneman, E. Davis, J. Deanfield, K. Donaghue, T.W. Jones, F.H. Mahmud, S.M. Marshall, H.A.W. Neil, H.M. Colhoun and D. Dunger
Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes
Pediatric Diabetes, 21 (7), 1322-1332, 2020
M.C. Barbu, A. Spiliopoulou, M. Colombo, P.M. McKeigue, T.-K. Clarke, D.M. Howard, M.J. Adams, X. Shen, S.M. Lawrie, A.M. McIntosh and H.C. Whalley
Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging
Translational Psychiatry, 10, 55, 2020
M. Colombo, S.J. McGurnaghan, L.A.K. Blackbourn, R.N. Dalton, D. Dunger, S. Bell, J.R. Petrie, F. Green, S. MacRury, J.A. McKnight, A. Collier, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators
Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes
Diabetologia, 63 (4), 788–798, 2020
M. Colombo, S.J. McGurnaghan, S. Bell, F. McKenzie, A.W. Patrick, J.R. Petrie, J.A. McKnight, S. MacRury, J. Traynor, W. Metcalfe, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators
Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus
Diabetologia, 63 (3), 636-647, 2020
P.M. McKeigue, A. Spiliopoulou, S.J. McGurnaghan, M. Colombo, L.A.K. Blackbourn, T.J. McDonald, S. Onengut-Gomuscu, S.S. Rich, C.N.A. Palmer, J.A. McKnight, M.W.J. Strachan, A.W. Patrick, J. Chalmers, R.S. Lindsay, J.R. Petrie, S. Thekkepat, A. Collier, S. MacRury and H.M. Colhoun
Persistent C-peptide secretion in type 1 diabetes and its relationship to the genetic architecture of diabetes
BMC Medicine, 17 (1), 165, 2019
M. Colombo°, E. Valo°, S.J. McGurnaghan, N. Sandholm, L.A.K. Blackbourn, R.N. Dalton, D. Dunger, P.H. Groop, P.M. McKeigue, C. Forsblom and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators and FinnDiane Study Group
Biomarkers associated with progression of renal disease in type 1 diabetes
Diabetologia, 62 (9), 1616-1627, 2019
A. Spiliopoulou, M. Colombo, D. Plant, J. Cui, M.J.H. Coenen, K. Ikari, H. Yamanaka, S. Saevarsdottir, L. Padyukov, S.L. Bridges Jr, R.P. Kimberly, Y. Okada, P.L.C.M. van Riel, I.E. van der Horst-Bruinsma, N. de Vries, P.P. Tak, K. Ohmura, H. Canhao, K-J. Guchelaar, T.W.J. Huizinga, L.A. Criswell, S. Raychaudhuri, M. Weinblatt, A.G. Wilson, X. Mariette, J. Isaacs, A.W. Morgan, MATURA Consortium, C. Pitzalis, A. Barton and P.M. McKeigue
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39
Annals of the Rheumatic Diseases, 78, 1055-1061, 2019
E.M.A. Hensor, P.M. McKeigue, S.F. Ling, M. Colombo, J.H. Barrett, J.L. Nam, J. Freeston, M.H. Buch, A. Spiliopoulou, F. Agakov, S. Kelly, M.J. Lewis, S.M.M. Verstappen, A.J. MacGregor, S. Viatte, A. Barton, C. Pitzalis, P. Emery, MATURA consortium, IACON consortium, PEAC consortium, P.G. Conaghan and A.W. Morgan
Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis
Rheumatology, 58 (8), 1400-1409, 2019
M. Colombo°, H.C. Looker°, B. Farran, S. Hess, L. Groop, C.N.A. Palmer, M.J. Brosnan, R.N. Dalton, M. Wong, C. Turner, E. Ahlqvist, D. Dunger, F. Agakov, P. Durrington, S. Livingstone, J. Betteridge, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT investigators
Serum kidney injury molecule 1 and beta-2-microglobulin perform as well as larger panels for prediction of rapid decline in renal function in type 2 diabetes
Diabetologia, 62 (1), 156-168, 2019
S. Cherlin, D. Plant, J.C. Taylor, M. Colombo, A. Spiliopoulou, E. Tzanis, A.W. Morgan, M.R. Barnes, P.M. McKeigue, J.H. Barrett, C. Pitzalis, A. Barton, MATURA Consortium and H.J. Cordell
Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data
Genetic Epidemiology, 42, 754-771, 2018
J. Massey, D. Plant, K. Hyrich, A.W. Morgan, A.G. Wilson, A. Spiliopoulou, M. Colombo, P.M. McKeigue, J. Isaacs, H. Cordell, C. Pitzalis, A. Barton, BRAGGSS, MATURA Consortium
Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis
The Pharmacogenomics Journal, 18, 657-664, 2018
M. Colombo°, H.C. Looker°, B. Farran, F. Agakov, M.J. Brosnan, P. Welsh, N. Sattar, S.J. Livingstone, P.N. Durrington, D.J. Betteridge, P.M. McKeigue and H.M. Colhoun
Apolipoprotein CIII and N-terminal prohormone b-type natriuretic peptide as independent predictors for cardiovascular disease in type 2 diabetes
Atherosclerosis, 274, 182-190, 2018
J.C. Taylor, T. Bongartz, J. Massey, B. Mifsud, A. Spiliopoulou, I.C. Scott, J. Wang, M. Morgan, D. Plant, M. Colombo, P. Orchard, S. Twigg, I.B. McInnes, D. Porter, J.E. Freeston, J.L. Nam, H.J. Cordell, J.D. Isaacs, J.L. Strathdee, D. Arnett, M.J.H. de Hair, P.P. Tak, S. Aslibekyan, R.F. van Vollenhoven, L. Padyukov, S.L. Bridges, C. Pitzalis, A.P. Cope, S.M.M. Verstappen, P. Emery, M.R. Barnes, F. Agakov, P.M. McKeigue, T. Mushiroda, M. Kubo, R. Weinshilboum, A. Barton, A.W. Morgan and J.H. Barrett, on behalf of the MATURA and PAMERA Consortia
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
The Pharmacogenomics Journal, 18, 528-538, 2018
M.L. Bermingham°, M. Colombo°, S.J. McGurnaghan, L.A.K. Blackbourn, F. Vučković, M. Pučić Baković, I. Trbojević-Akmačić, G. Lauc, F. Agakov, A. Agakova, C. Hayward, L. Klarić, C.N.A. Palmer, J.R. Petrie, J. Chalmers, A. Collier, F. Green, R.S. Lindsay, S. MacRury, J.A. McKnight, A.W. Patrick, S. Thekkepat, O. Gornik, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRN Type 1 Bioresource Investigators
N-glycan profile and kidney disease in type 1 diabetes
Diabetes Care, 41 (1), 79-87, 2018
N. Pirastu, P.K. Joshi, P.S. de Vries, M.C. Cornelis, P.M. McKeigue, N. Keum, N. Franceschini, M. Colombo, E.L. Giovannucci, A. Spiliopoulou, L. Franke, K.E. North, P. Kraft, A.C. Morrison, T. Esku and J.F. Wilson
GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
Nature Communications, 8, 1584, 2017
J.D. Quell, W. Römisch-Margl, M. Colombo, J. Krumsiek, A.M. Evans, R. Mohney, V. Salomaa, U. de Faire, L.C. Groop, F. Agakov, H.C. Looker, P.M. McKeigue, H.M. Colhoun and G. Kastenmüller
Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies
Journal of Chromatography B, 1071, 58-67, 2017
A. Spiliopoulou, M. Colombo, P. Orchard, F. Agakov and P.M. McKeigue
GeneImp: fast imputation to large reference panels using genotype likelihoods from ultralow coverage sequencing
Genetics, 206 (1), 91-104, 2017
H.C. Looker°, M. Colombo°, S. Hess, M.J. Brosnan, B. Farran, R.N. Dalton, M.C. Wong, C. Turner, C.N.A. Palmer, E. Nogoceke, L. Groop, V. Salomaa, D.B. Dunger, F. Agakov, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT Investigators
Biomarkers of rapid chronic kidney disease progression in type 2 diabetes
Kidney International, 88 (4), 888-896, 2015
H.C. Looker, M. Colombo, F. Agakov, T. Zeller, L. Groop, B. Thorand, C.N. Palmer, A. Hamsten, U. de Faire, E. Nogoceke, S.J. Livingstone, V. Salomaa, K. Leander, N. Barbarini, R. Bellazzi, N. van Zuydam, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT Investigators
Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes
Diabetologia, 58 (6), 1363-1371, 2015
P.M. McKeigue, M. Colombo, F. Agakov, I. Datta, A. Levin, D. Favro, R.R. Burke, C. Gray-Montgomery, M.C. Iannuzzi and B.A. Rybicki
Extending admixture mapping to nuclear pedigrees: application to sarcoidosis
Genetic Epidemiology, 37 (3), 256-266, 2013
M. Colombo and A. Grothey
A decomposition-based crash-start method for stochastic programming
Computational Optimization and Applications, 55 (2), 311-340, 2013
B.A. Rybicki, A.M. Levin, P.M. McKeigue, I. Datta, C. Gray-McGuire, M. Colombo, D. Reich, R.R. Burke and M.C. Iannuzzi
A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans
Genes and Immunity, 12 (2), 67-77, 2011
M. Colombo, J. Gondzio and A. Grothey
A warm-start approach for large-scale stochastic linear programs
Mathematical Programming, 127 (2), 371-397, 2011
M. Colombo, A. Grothey, J. Hogg, K. Woodsend and J. Gondzio
A structure-conveying modelling language for mathematical and stochastic programming
Mathematical Programming Computation, 1 (4), 223-247, 2009
A. Grothey, J. Hogg, K. Woodsend, M. Colombo and J. Gondzio
A structure-conveying parallelisable modelling language for mathematical programming
"Parallel Scientific Computing and Optimization", R. Ciegis, D. Henty, B. Kågström, J. Zilinskas (eds.), Springer Optimization and its Applications, 27, 147-158, 2009
M. Colombo and J. Gondzio
Further development of multiple centrality correctors for interior point methods
Computational Optimization and Applications, 41 (3), 277-305, 2008
Technical reports and Dissertations
September 2020
M. Colombo, J. Mellor, H.M. Colhoun, M.G.M. Gomes and P.M. McKeigue
Trajectory of COVID-19 epidemic in Europe
medRxiv
June 2009, revised December 2010
M. Colombo and A. Grothey
A multi-step interior point warm-start approach for large-scale stochastic linear programming
Technical Report ERGO 09-007
May 2007, revised October 2007
M. Colombo
Advances in interior point methods for large-scale linear programming
Thesis presented for the Degree of PhD in Optimization, School of Mathematics, University of Edinburgh
Successfully defended on 6 September 2007, examiners Danny Ralph and Ken McKinnon
September 2003
M. Colombo
A branch-and-cut approach to solve the Hamiltonian Cycle Problem
Dissertation presented for the Degree of MSc in Operational Research, School of Mathematics, University of Edinburgh
MSc in OR awarded with distinction